Which of the following statements is true regarding the transfer of controlled substances?

The statement regarding the transfer of controlled substances that is true is that C3-C5 prescriptions can be transferred once for refill purposes. This is consistent with federal regulations, which allow for the transfer of prescriptions for Schedule III, IV, and V controlled substances. Specifically, a prescription for these schedules can be transferred a single time to a different pharmacy for the purpose of obtaining a refill. This transfer is governed by regulations that are intended to maintain control over the distribution of these substances while allowing for patient access to necessary medications.

In contrast, the other options presented do not align with the established regulations. For instance, C2 prescriptions cannot be transferred between pharmacies—this is strictly prohibited under federal law. Legend drugs, while typically not subjected to the same stringent regulations as controlled substances, may still have some limitations regarding transfers based on individual state laws and pharmacy policies. Lastly, C2 prescriptions cannot be re-dispensed at any pharmacy; they are subject to strict handling and storage requirements, and transfers are not permitted. Understanding these distinctions is crucial for compliance with pharmacy regulations.