What amount of codeine is necessary to create a CIII medication?

To classify a medication containing codeine as a Schedule III controlled substance, there are specific limits set by the Drug Enforcement Administration (DEA) regarding the amount of codeine allowable in a preparation. For a product to be classified as CIII, it must contain no more than 1.8 grams of codeine per 100 milliliters or per 100 grams.

Given that the correct answer indicates the presence of 1.8 grams in 100 mLs, this aligns perfectly with the established regulations governing Schedule III substances. Medications that exceed this limit, like those containing 2.5 grams in 100 mLs, would fall into a different category, specifically Schedule II, due to their higher concentration of codeine.

Therefore, the chosen option effectively represents the threshold at which codeine's classification transition occurs, marking a significant point in understanding the scheduling of controlled substances and their regulatory measures in pharmacy practice.